百里香酚
炎症性肠病
氧化应激
医学
背景(考古学)
促炎细胞因子
炎症
溃疡性结肠炎
免疫学
疾病
免疫系统
病因学
肠道菌群
内科学
生物
精油
古生物学
食品科学
作者
Yao Liu,Hui Yan,Bing Yu,Jun He,Xiangbing Mao,J. Yu,Ping Zheng,Zhiqing Huang,Yuheng Luo,Junqiu Luo,Aimin Wu,Daiwen Chen
出处
期刊:Antioxidants
[MDPI AG]
日期:2022-09-29
卷期号:11 (10): 1947-1947
标识
DOI:10.3390/antiox11101947
摘要
Inflammatory bowel disease (IBD) is a gastrointestinal disease that involves chronic mucosal or submucosal lesions that affect tissue integrity. Although IBD is not life-threatening, it sometimes causes severe complications, such as colon cancer. The exact etiology of IBD remains unclear, but several risk factors, such as pathogen infection, stress, diet, age, and genetics, have been involved in the occurrence and aggravation of IBD. Immune system malfunction with the over-production of inflammatory cytokines and associated oxidative stress are the hallmarks of IBD. Dietary intervention and medical treatment suppressing abnormal inflammation and oxidative stress are recommended as potential therapies. Thymol, a natural monoterpene phenol that is mostly found in thyme, exhibits multiple biological functions as a potential adjuvant for IBD. The purpose of this review is to summarize current findings on the protective effect of thymol on intestinal health in the context of specific animal models of IBD, describe the role of thymol in the modulation of inflammation, oxidative stress, and gut microbiota against gastrointestinal disease, and discuss the potential mechanism for its pharmacological activity.
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