逆行信号
细胞生物学
生物
胞浆
调节器
细胞器
热休克蛋白90
叶绿体
生物发生
表型
秀丽隐杆线虫
遗传筛选
拟南芥
伴侣(临床)
信号转导
基因
生物化学
突变体
遗传学
热休克蛋白
病理
酶
医学
作者
Guo-Zhang Wu,Etienne H. Meyer,Andreas Richter,Maja Schuster,Qihua Ling,Mark Aurel Schöttler,Dirk Walther,Reimo Zoschke,Bernhard Grimm,Paul Jarvis,Ralph Bock
出处
期刊:Nature plants
[Springer Nature]
日期:2019-05-06
卷期号:5 (5): 525-538
被引量:104
标识
DOI:10.1038/s41477-019-0415-y
摘要
Communication between organelles and the nucleus is essential for fitness and survival. Retrograde signals are cues emitted from the organelles to regulate nuclear gene expression. GENOMES UNCOUPLED1 (GUN1), a protein of unknown function, has emerged as a central integrator, participating in multiple retrograde signalling pathways that collectively regulate the nuclear transcriptome. Here, we show that GUN1 regulates chloroplast protein import through interaction with the import-related chaperone cpHSC70-1. We demonstrated that overaccumulation of unimported precursor proteins (preproteins) in the cytosol causes a GUN phenotype in the wild-type background and enhances the GUN phenotype of the gun1 mutant. Furthermore, we identified the cytosolic HSP90 chaperone complex, induced by overaccumulated preproteins, as a central regulator of photosynthetic gene expression that determines the expression of the GUN phenotype. Taken together, our results suggest a model in which protein import capacity, folding stress and the cytosolic HSP90 complex control retrograde communication. Retrograde signalling ensures message communication between organelles and the nucleus. A pivotal regulator of plant retrograde signalling, GENOMES UNCOUPLED1, is now found to regulate protein import into chloroplast during chloroplast biogenesis or under stress conditions.
科研通智能强力驱动
Strongly Powered by AbleSci AI