和男人发生性关系的男人
假阳性悖论
人类免疫缺陷病毒(HIV)
HIV筛查
病毒学
Dna检测
医学
生物
免疫学
DNA
遗传学
统计
梅毒
数学
作者
Kai Chen,Yuehua Wang,Xijia He,Jun Yao,Dongyan Xia,Hongzhou Lu,Yan Jiang
标识
DOI:10.1089/aid.2019.0091
摘要
Rapid test (RT) is the principal screening method in the HIV control practice. However, this method may lead to inaccurate detection, primarily due to the more than 4 weeks of window phase. In the present study, we performed a HIV DNA screening method to show its application prospects in men who have sex with men (MSM). From July 2017 to April 2018, we recruited 1,301 MSM from Beijing who were not previously diagnosed as HIV positive. Both HIV DNA detection and RT were performed. In total, 141 and 135 HIV-positive results were detected by DNA detection and RT, respectively. By repetitive and confirmative tests (Western blot), we verified that DNA detection detected 10 more true positives than RT and 4 false positives were corrected from RT. This represents 14 inaccurate RT results that were corrected by DNA measurement. Therefore, DNA measurement should be fully considered as a screening method in the detection of HIV among MSM in the future.
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