医学
慢性阻塞性肺病
慢性支气管炎
流行病学
肺活量测定
共病
自然史
哮喘
内科学
遗传流行病学
物理疗法
重症监护医学
作者
Diego J. Maselli,Surya P. Bhatt,Antonio Anzueto,Russell P. Bowler,Dawn L. DeMeo,Alejandro A. Díaz,Mark T. Dransfield,Ashraf Fawzy,Marilyn G. Foreman,Nicola A. Hanania,Craig P. Hersh,Victor Kim,Gregory L. Kinney,Nirupama Putcha,Emily S. Wan,James M. Wells,Gloria Westney,Kendra A. Young,Edwin K. Silverman,Mei Lan K. Han,Barry J. Make
出处
期刊:Chest
[Elsevier]
日期:2019-08-01
卷期号:156 (2): 228-238
被引量:57
标识
DOI:10.1016/j.chest.2019.04.135
摘要
The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and biomarker profiling. The objective of this review was to summarize the major advances in the clinical epidemiology of COPD from the first 10 years of the COPDGene study. We highlight the influence of age, sex, and race on the natural history of COPD, and the impact of comorbid conditions, chronic bronchitis, exacerbations, and asthma/COPD overlap.
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