硼氢化
对映选择合成
化学
催化作用
配体(生物化学)
背景(考古学)
组合化学
金属
镁
有机化学
生物化学
生物
古生物学
受体
作者
Alban Falconnet,Marc Magre,Bholanath Maity,Luigi Cavallo,Magnus Rueping
标识
DOI:10.1002/anie.201908012
摘要
Asymmetric catalysis with readily available, cheap, and non-toxic alkaline earth metal catalysts represents a sustainable alternative to conventional synthesis methodologies. In this context, we describe the development of a first MgII -catalyzed enantioselective hydroboration providing the products with excellent yields and enantioselectivities. NMR spectroscopy studies and DFT calculations provide insights into the reaction mechanism and the origin of the enantioselectivity which can be explained by a metal-ligand cooperative catalysis pathway involving a non-innocent ligand.
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