Catalyst‐free one‐pot synthesis of a new class of 2H‐furo[3,2‐c]chromene‐2,4(3H)‐dione and arylamino‐bis(coumarin)methane derivatives on water

Abstract A catalyst‐free, environmentally benign, and simple procedure has been developed for the efficient synthesis of novel 2 H ‐furo[3,2‐ c ]chromene‐2,4(3 H )‐dione and 3,3′‐((arylamino)methylene)bis(4‐hydroxycoumarin) derivatives from one‐pot three‐component condensation of 4‐hydroxycoumarin, glyoxalic acid monohydrate and various amines in water under reflux condition. In this green synthetic protocol, the solvent water itself catalyzed the reaction via hydrogen bonding. One‐pot, high yields, short reaction times, simple operation, environmental friendly and easy workup procedure are highlights. This is the first report for the synthesis of 2 H ‐furo[3,2‐ c ]chromene‐2,4(3 H )‐dione and arylamino‐bis(coumarin)methane derivatives.