冲程(发动机)
血脑屏障
超氧化物歧化酶
神经保护
丙二醛
脑梗塞
活性氧
医学
缺血
药理学
过氧化氢酶
氧化应激
化学
神经科学
中枢神经系统
内科学
生物化学
生物
机械工程
工程类
作者
Bing Chun Yan,Jianwen Cao,Jiajia Li,Yunhao Gu,Zhuobin Xu,Dandan Li,Lizeng Gao
出处
期刊:ACS Biomaterials Science & Engineering
[American Chemical Society]
日期:2020-12-21
卷期号:7 (1): 299-310
被引量:31
标识
DOI:10.1021/acsbiomaterials.0c01312
摘要
Cerebral ischemic stroke stimulates excessive reactive oxygen species, which lead to blood–brain-barrier disruption, neuron death, and aggravated cerebral infarction. Thus, it is critical to develop an antioxidant strategy for stroke treatment. Herein, we report a dietary strategy to promote stroke healing using iron oxide (Fe3O4) nanoparticles with intrinsic enzyme-like activities. We find that Fe3O4 nanozymes exhibit triple enzyme-like activities, peroxidase, catalase, and superoxide dismutase, thus potentially possessing the ability to regulate the ROS level. Importantly, intragastric administration of PEG-modified Fe3O4 nanozymes significantly reduces cerebral infarction and neuronal death in a rodent model following cerebral ischemic stroke. Ex vivo analysis shows that PEG-modified Fe3O4 nanozymes localize in the cerebral vasculature, ameliorate local redox state with decreased malondialdehyde and increased Cu/Zn SOD, and facilitate blood–brain-barrier recovery by elevating ZO-1 and Claudin-5 in the hippocampus. Altogether, our results suggest that dietary PEG-modified Fe3O4 nanozymes can facilitate blood–brain-barrier reconstruction and protect neurons following ischemic stroke.
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