This paper analyzed the impact of sulfuric acid concentration and temperature on leaching of metal ions from Zn-MnO cell.The experimental results indicated that the optimal technological conditions were:10% H2SO4 concentration,40 ℃,1:10 solid-to-liquid ratio,1mL catalyst,2-hour reaction time and 40 ~80 r/min stirring intensity.Under these conditions,the leaching ratio of Zn2+ was at least 99%,and about 80% for Mn2+,at least 50% for Fe2+,and lower for other harmful metals.This study could provide some references for separating harmful metal and producing chelated fertilizer with waste Zn-MnO cell.