This paintings changed into carried out to analyze the impact of choice for expanded frame weight on immune reaction parameters in 2nd technology of Nile tilapia, Oreochromis niloticus through amassing 8 fish from decided on full-sib households and 8 fish from manage breed line. Blood samples had been gathered from the fish caudal peduncle of the 2 groups, and immune reaction parameters had been measured as overall protein, albumin, and globulin, ALT, AST, Urea, and creatinine, lysozyme activity, bactericidal activity, overall lipid, trigylcerol, overall cholesterol, and hematological parameters. The consequences discovered that the immune reaction parameters had been better in decided on breed line than manage breed line and this concluded that choice for expanded frame weight advanced immune reaction and capabilities which play a position in disorder resistance.