A Ligand Exchange Process for the Diversification of Palladium Oxidative Addition Complexes.
催化作用
氧化磷酸化
配体(生物化学)
药物化学
作者
Ryan P. King,Shane W. Krska,Stephen L. Buchwald
出处
期刊:Organic Letters [American Chemical Society] 日期:2021-07-28卷期号:23 (15): 6030-6034被引量:1
标识
DOI:10.1021/acs.orglett.1c02101
摘要
Palladium oxidative addition complexes (OACs) have recently emerged as useful tools to enable challenging bond connections. However, each OAC can only be formed with one dative ligand at a time. As no one ligand is optimal for every cross-coupling reaction, we herein disclose a ligand exchange protocol for the preparation of a series of OACs bearing a variety of ancillary ligands from one common complex. These complexes were further applied to cross-coupling transformations.