化学
催化作用
检出限
生物传感器
组合化学
级联
过氧化物酶
交货地点
选择性
纳米技术
酶
色谱法
生物化学
农学
生物
材料科学
作者
Yifeng Chen,Lei Jiao,Hongye Yan,Weiqing Xu,Yu Wu,Lirong Zheng,Wenling Gu,Chengzhou Zhu
出处
期刊:Analytical Chemistry
[American Chemical Society]
日期:2021-09-01
卷期号:93 (36): 12353-12359
被引量:58
标识
DOI:10.1021/acs.analchem.1c02115
摘要
Although single-atom catalysts with high enzyme-like activities have been found, the rational design of highly active peroxidase (POD)-like nanozymes is still a formidable challenge. Herein, highly active POD-like nanozymes were synthesized through loading Pt clusters on the Fe single-atom (FeSA–PtC) nanozymes. The POD-like activity of FeSA–PtC nanozymes is enhanced 4.5-fold and 7-fold, in comparison to that of FeSA and PtC nanozymes, respectively, which is attributed to the unexpected synergistic effect between Fe single atoms and Pt clusters. Based on the outstanding POD-like activity of FeSA–PtC nanozymes, a cascade signal amplification strategy was constructed by combining glucose oxidase for the colorimetric biosensing of prostate-specific antigens, exhibiting satisfactory sensitivity, high selectivity, a low detection limit of 1.8 pg/mL, and practical feasibility in serum sample detection. This work may serve as a tough foundation to guide the design of superior POD-like nanozymes and expand the application in biosensing.
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