生物导体
注释
集合(抽象数据类型)
可视化
接口(物质)
数据集
计算机科学
数据科学
情报检索
数据挖掘
生物
基因
人工智能
程序设计语言
最大气泡压力法
气泡
并行计算
生物化学
作者
Tianzhi Wu,Erqiang Hu,Shuaimei Xu,Meijun Chen,Pingfan Guo,Zhigang Dai,Tingze Feng,Lang Zhou,Wenli Tang,Zhan Li,Xiaocong Fu,Shanshan Liu,Xiaochen Bo,Guangchuang Yu
出处
期刊:The Innovation
[Elsevier]
日期:2021-08-01
卷期号:2 (3): 100141-100141
被引量:2659
标识
DOI:10.1016/j.xinn.2021.100141
摘要
Functional enrichment analysis is pivotal for interpreting high-throughput omics data in life science. It is crucial for this type of tool to use the latest annotation databases for as many organisms as possible. To meet these requirements, we present here an updated version of our popular Bioconductor package, clusterProfiler 4.0. This package has been enhanced considerably compared with its original version published 9 years ago. The new version provides a universal interface for functional enrichment analysis in thousands of organisms based on internally supported ontologies and pathways as well as annotation data provided by users or derived from online databases. It also extends the dplyr and ggplot2 packages to offer tidy interfaces for data operation and visualization. Other new features include gene set enrichment analysis and comparison of enrichment results from multiple gene lists. We anticipate that clusterProfiler 4.0 will be applied to a wide range of scenarios across diverse organisms.
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