颈肌张力障碍
中央前回
神经科学
肌张力障碍
局灶性肌张力障碍
小脑
静息状态功能磁共振成像
辅助电机区
运动皮层
体感系统
基底神经节
中央后回
心理学
皮质(解剖学)
医学
功能磁共振成像
磁共振成像
中枢神经系统
刺激
放射科
作者
Giuseppe Zito,Clément Tarrano,Prasanthi Jegatheesan,Asya Ekmen,Benoit Beranger,Michael Rebsamen,Cécile Hubsch,S. Sangla,Cecilia Bonnet,Cécile Delorme,Aurélie Méneret,Bertrand Degos,F. Bouquet,Marion Apoil Brissard,Marie Vidailhet,Cécile Gallea,Emmanuel Roze,Yulia Worbe
标识
DOI:10.1016/j.parkreldis.2021.11.034
摘要
Cervical dystonia is the most frequent form of isolated focal dystonia. It is often associated with a dysfunction in brain networks, mostly affecting the basal ganglia, the cerebellum, and the somatosensory cortex. However, it is unclear if such a dysfunction is somato-specific to the brain areas containing the representation of the affected body part, and may thereby account for the focal expression of cervical dystonia. In this study, we investigated resting state functional connectivity in the areas within the motor cortex and the cerebellum containing affected and non-affected body representations in cervical dystonia patients.Eighteen patients affected by cervical dystonia and 21 healthy controls had resting state fMRI. The functional connectivity between the motor cortex and the cerebellum, as well as their corresponding measures of gray matter volume and cortical thickness, were compared between groups. We performed seed-based analyses, selecting the different body representation areas in the precentral gyrus as seed regions, and all cerebellar areas as target regions.Compared to controls, patients exhibited increased functional connectivity between the bilateral trunk representation area of the motor cortex and the cerebellar vermis 6 and 7b, respectively. These functional abnormalities did not correlate with structural changes or symptom severity.Our findings indicate that the abnormal function of the motor network is somato-specific to the areas encompassing the neck representation. Functional abnormalities in discrete relevant areas of the motor network could thus contribute to the focal expression of CD.
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