This work was aimed to evaluate the Modified Dephanox process, in which rotating blo-contactor (RBC) is incorporated into the process as an independent nitrification reactor, in treating domestic and industrial wastewater. Pilot-scale experimental results showed that the removal efficiencies of total chemical oxygen demand (TCOD), soluble chemical oxygen demand (SCOD), total phosphorus (T-P) and total nitrogen (T-N) in treating domestic wastewater were higher than those in treating industrial wastewater. The removals of TCOD, SCOD, T-P and T-N in treating domestic wastewater were 90, 82. 95 and 80 %, whereas those in treating industrial wastewater were 75, 65, 75 and 65 %, respectively, The lower efficiencies of TCOD, SCOD, T-P and T-P of industrial wastewater would be attributed to toxic materials, such as heavy metals, which could be contained in industrial wastewater. Consequently, the M-Dephanox system proposed in this study contributed to the high and stable removal efficiency of TCOD, SCOD, T-P and T-N of domestic wastewater. However, the Modified Dephanox system was significantly vulnerable to toxic materials even though the system was designed to minimize the toxic effects (specifically to enhance nitrification) by introducing the RBC reactor.