The Protective Actions of Exercise on Bone Formation, the Relationship between FNDC5/Irisin and Autophagy

Most researchers have recognized the beneficial effects of exercise on bone formation in the organism. Irisin released from muscles is considered to be the link between muscles and other organs, and its main function is to change subcutaneous and visceral adipose tissue into brown adipose tissue, with a consequent increase in thermogenesis. Irisin can regulate glucose metabolism, bone metabolic homeostasis, and systemic inflammatory response