MPTP公司
神经保护
酪氨酸羟化酶
蛋白核小球藻
神经毒性
多巴胺
免疫系统
帕金森病
药理学
肿瘤坏死因子α
化学
免疫学
生物
内分泌学
医学
内科学
多巴胺能
毒性
疾病
小球藻
藻类
生态学
作者
Phoebe B. Chen,Hsiao‐Chi Wang,Yen-Wenn Liu,Shih-Hang Lin,Hong‐Nong Chou,Lee‐Yan Sheen
标识
DOI:10.1016/j.jff.2014.08.019
摘要
Neuro-inflammation is implicated as a major pathogenic factor in Parkinson's disease (PD). Dietary supplements of Chlorella pyrenoidosa possess great anti-inflammatory activities, but its neuroprotective effect remains unclear. The aim of this study was to investigate the effects of polysaccharides from Chlorella pyrenoidosa (CPS) on motor activity, dopamine expressions, microglial activation, and peripheral immunomodulatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced mouse model of PD. The results of this study indicated that CPS reduced bradykinesia, inhibited the loss of striatal dopamine and its metabolites, and led to an increase in tyrosine hydroxylase in PD mice. In addition, CPS also suppressed the striatal Emr1 expression and tumor necrosis factor-α, interleukin-1β and IL-6 levels in serum. Furthermore, the gut immune biomarkers such as serum diamine oxidase and small intestinal secretory immunoglobulin A were enhanced by CPS treatment. These findings demonstrate that CPS has protective effect in MPTP-induced neurotoxicity in this model of PD via its immunomodulatory action.
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