Hydrolytic Transformation of Microporous Metal–Organic Frameworks to Hierarchical Micro‐ and Mesoporous MOFs

A new approach to the synthesis of hierarchical micro- and mesoporous MOFs from microporous MOFs involves a simple hydrolytic post-synthetic procedure. As a proof of concept, a new microporous MOF, POST-66(Y), was synthesized and its transformation into a hierarchical micro- and mesoporous MOF by water treatment was studied. This method produced mesopores in the range of 3 to 20 nm in the MOF while maintaining the original microporous structure, at least in part. The degree of micro- and mesoporosity can be controlled by adjusting the time and temperature of hydrolysis. The resulting hierarchical porous MOF, POST-66(Y)-wt, can be utilized to encapsulate nanometer-sized guests such as proteins, and the enhanced stability and recyclability of an encapsulated enzyme is demonstrated.