免疫分析
化学
肌红蛋白
分析物
微流控
肌钙蛋白I
血管内皮生长因子
肌钙蛋白复合物
纳米技术
基质(水族馆)
色谱法
抗体
血管内皮生长因子受体
内科学
生物化学
免疫学
医学
心肌梗塞
材料科学
海洋学
地质学
作者
Terence G. Henares,Fumio Mizutani,Hideaki Hisamoto
标识
DOI:10.1016/j.aca.2008.01.064
摘要
This review accounts for the current development in microfluidic immunosensing chips. The basic knowledge of immunoassay in relation to its microfluidic material substrate, fluid handling and detection mode are briefly discussed. Here, we mainly focused on the surface modification, antibody immobilization, detection, signal enhancement and multiple analyte sensing. Some of the clinically important currently implemented on the microfluidic immunoassay chips are C-reactive protein (CRP), prostate specific antigen (PSA), ferritin, vascular endothelial growth factor (VEGF), myoglobin (Myo), cardiac troponin T (cTnT), cardiac troponin I (cTnI), and creatine kinase-cardiac muscle isoform (CK-MB). The emerging microfludic immunosensor technology may be a promising prospect that can propel the improvement of clinical and medical diagnosis.
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