Nongenetic stochastic expansion of JAK2V617F-homozygous subclones in polycythemia vera?

To the editor: The JAK2V617F mutation is found in most patients with polycythemia vera (PV) and 50% to 60% of those with essential thrombocythemia (ET). JAK2V617F -homozygous precursors arise through mitotic recombination, form larger clones in PV compared with ET,[1][1] and may play a causal role