Abstract A hybridized system is described for the continuous-flow determination of serum calcium. The analysis is based on the cresolphthalein colorimetric procedure as described for use with the SMA 12/60 (Technicon Corp.). The hydraulic features of the AutoAnalyzer II are used with modules of the AutoAnalyzer I. This combination gives both the ease of operation and hydraulic improvements inherent in the AutoAnalyzer II system and provides an emergency alternative to the SMA 12/60, with which results are shown to be comparable.