The Transcriptional Landscape of the Mammalian Genome

聚腺苷酸生物基因组转录组 RNA剪接选择性拼接遗传学基因转录调控计算生物学抄写（语言学）转录因子基因表达信使核糖核酸核糖核酸哲学语言学

作者

Piero Carninci,Takeya Kasukawa,Shintaro Katayama,Julian Gough,Martin C. Frith,Norihiro Maeda,Rieko Oyama,Timothy Ravasi,Boris Lenhard,Christine A. Wells,Rimantas Kodzius,Koya Shimokawa,Vladimir B. Bajić,Steven E. Brenner,Serge Batalov,Alistair R. R. Forrest,Mihaela Zavolan,Melissa J. Davis,Laurens Wilming,Vassilis Aidinis,Jonathan Allen,Alberto Ambesi‐Impiombato,Rolf Apweiler,Rajith Aturaliya,Timothy L. Bailey,Mukul S. Bansal,Laura L. Baxter,Kirk W. Beisel,Tom Bersano,Hidemasa Bono,Alistair M. Chalk,Kuo Ping Chiu,Vijayata Choudhary,Alan Christoffels,D. R. Clutterbuck,Mark L. Crowe,Emiliano Dalla,Brian P. Dalrymple,Bernard de Bono,Giusy Della Gatta,Diego di Bernardo,Thomas A. Down,Pär G. Engström,Michela Fagiolini,Geoffrey J. Faulkner,Colin Fletcher,Tatsuya Fukushima,Masaaki Furuno,Sugiko Futaki,Manuela Gariboldi,Patrik Georgii‐Hemming,T Gingeras,Takashi Gojobori,Richard E. Green,Stefano Gustincich,Matthias Harbers,Yoshitaka Hayashi,Takao K. Hensch,Nobutaka Hirokawa,David E. Hill,Łukasz Huminiecki,Michele Iacono,Kazuho Ikeo,Atsushi Iwama,Takanori Ishikawa,Lars Martin Jakt,Alexander Kanapin,Masaru Katoh,Yuka Imamura Kawasawa,Janet Kelso,Hiroshi Kitamura,Hiroaki Kitano,George Kollias,Sivanand Krishnan,Adéle Kruger,Sarah Kummerfeld,Igor V. Kurochkin,Liana F. Lareau,Dejan Lazarević,Leonard Lipovich,Jinfeng Liu,Sabino Liuni,Sean McWilliam,M. Madan Babu,Martin Madera,Luigi Marchionni,Hideo Matsuda,Shu‐ichi Matsuzawa,Hiroaki Miki,Flavio Mignone,S. Miyake,Ken A. Morris,Salim Mottagui‐Tabar,Nicola Mulder,Norio Nakano,Hiromitsu Nakauchi,Patrick Ng,Roland Nilsson,Seiji Nishiguchi,Shigemichi Nishikawa,Franco Nori,Osamu Ohara,Yasushi Okazaki,Valerio Orlando,Ken C. Pang,William J. Pavan,Giulio Pavesi,Graziano Pesole,Nikolai Petrovsky,Silvano Piazza,James Reed,James F. Reid,Brian Z. Ring,Martin Ringwald,Burkhard Rost,Yijun Ruan,Steven L. Salzberg,Albin Sandelin,C. Schneider,Christian Schönbach,Kiyotoshi Sekiguchi,Colin A. Semple,Shigeto Seno,Luca Sessa,Ying Sheng,Yûkô Shibata,Hiroshi Shimada,Kiyo Shimada,D. Silva,Bella Sinclair,Silke Sperling,Elia Stupka,Koji Sugiura,Răzvan Sultana,Yasuhiro Takenaka,Kohei Taki,Kairi Tammoja,Sin Lam Tan,Tang Suisheng,Martin S. Taylor,Jesper Tegnér,Sarah A. Teichmann,Hiroki R. Ueda,Erik van Nimwegen,Roberto Verardo,Chia Lin Wei,Ken Yagi,Hiromichi Yamanishi,Eugene R. Zabarovsky,Shanshan Zhu,Andreas Zimmer,Yoshihide Hayashizaki,Carol J. Bult,Sean M. Grimmond,Rohan D. Teasdale,E. T. Liu,Vladimir Brusić,John Quackenbush,Claes Wahlestedt,John S. Mattick,David Hume,Kai Cui,Daisuke Sasaki,Yuji Tomaru,Shiro Fukuda,Mutsumi Kanamori-Katayama,Masanori Suzuki,Juliana Ide Aoki,Takahiro Arakawa,Juri Iida,Yuka Imamura Kawasawa,Masayoshi Itoh,Tomomi Kato,Hideya Kawaji,Nobuyuki Kawagashira,Tsugumi Kawashima,Miki Kojima,Shinji Kondo,Hiroyuki Konno,Kenji Nakano,N. Ninomiya,T. Nishio,Mitsuhiro Okada,Charles Plessy,Kazuhiro Shibata,Toshiyuki Shiraki,Satoru Suzuki,Michihira Tagami,Kazunori Waki,Akira Watahiki,Yuko Okamura-Oho,Harukazu Suzuki,Jun Kawai,Yoshihide Hayashizaki

出处

期刊：Science [American Association for the Advancement of Science]
日期：2005-09-01 卷期号：309 (5740): 1559-1563 被引量：3422

链接

nih.govdoi.org

标识

DOI：10.1126/science.1112014

摘要

This study describes comprehensive polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome. We identify the 5′ and 3′ boundaries of 181,047 transcripts with extensive variation in transcripts arising from alternative promoter usage, splicing, and polyadenylation. There are 16,247 new mouse protein-coding transcripts, including 5154 encoding previously unidentified proteins. Genomic mapping of the transcriptome reveals transcriptional forests, with overlapping transcription on both strands, separated by deserts in which few transcripts are observed. The data provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.

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The Transcriptional Landscape of the Mammalian Genome

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