PLGA公司
乙烯醇
牛血清白蛋白
化学工程
乳状液
多孔性
控制释放
自愈水凝胶
化学
材料科学
聚合物
高分子化学
纳米技术
色谱法
复合材料
纳米颗粒
工程类
作者
Guohua Zhang,Ruixia Hou,Dan-Xia Zhan,Yang Cong,Ya‐Jun Cheng,Jun Fu
标识
DOI:10.1016/j.cclet.2013.05.011
摘要
This letter reports on the fabrication of hollow, porous and non-porous poly(d,l-lactide-co-glycolide) (PLGA) microspheres (MSs) for the controlled release of protein and promotion of cell compatibility of tough hydrogels. PLGA MSs with different structures were prepared with modified double emulsion methods, using bovine serum albumin (BSA) as a porogen during emulsification. The release of the residual BSA from PLGA MSs was investigated as a function of the MS structure. The hollow PLGA MSs show a faster protein release than the porous MSs, while the non-porous MSs have the slowest protein release. Compositing the PLGA MSs with poly(vinyl alcohol) (PVA) hydrogels promoted chondrocyte adhesion and proliferation on the hydrogels.
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