A Concise Total Synthesis of 7-Substituted Eudistomin Analogs

We report herein an optimized practical synthesis of three novel 7-substituted eudistomin analogs (1-3). The total syntheses of these complex tetracyclic molecules were completed in 22 steps from the requisite 7-substituted indoles. Keywords: demethylation, diasteroselectivity, Pictet-Spengler cyclization, total Synthesis, Eudistomin analogs