心脏发育
生物
形态发生
进化生物学
基因
系统发育树
计算生物学
胚胎干细胞
遗传学
作者
Eric N. Olson,Deepak Srivastava
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:1996-05-03
卷期号:272 (5262): 671-676
被引量:471
标识
DOI:10.1126/science.272.5262.671
摘要
Heart formation requires complex interactions among cells from multiple embryonic origins. Recent studies have begun to reveal the genetic pathways that control cardiac morphogenesis. Many of the genes within these pathways are conserved across vast phylogenetic distances, which has allowed cardiac development to be dissected in organisms ranging from flies to mammals. Studies of cardiac development have also revealed the molecular defects underlying several congenital cardiac malformations in humans and may ultimately provide opportunities for genetic testing and intervention.
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