磷酸化
激酶
磷酸酶
τ蛋白
细胞生物学
蛋白激酶A
生物
蛋白质磷酸化
神经科学
阿尔茨海默病
化学
疾病
生物化学
医学
内科学
作者
Ludovic Martin,Xénia Latypova,Cornelia M. Wilson,Amandine Magnaudeix,Marie-Laure Perrin,Catherine Yardin,Faraj Terro
标识
DOI:10.1016/j.arr.2012.06.003
摘要
Tau phosphorylation is regulated by a balance between tau kinase and phosphatase activities. Disruption of this equilibrium was suggested to be at the origin of abnormal tau phosphorylation and thereby might contribute to tau aggregation. Thus, understanding the regulation modes of tau phosphorylation is of high interest in determining the possible causes at the origin of the formation of tau aggregates in order to elaborate protection strategies to cope with these lesions in Alzheimer's disease. Among the possible and specific interventions that reverse tau phosphorylation is the inhibition of certain tau kinases. Here, we extensively reviewed tau protein kinases, their physiological roles and regulation, their involvement in tau phosphorylation and their relevance to AD. We also reviewed the most common inhibitory compounds acting on each tau kinase.
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