Porous aromatic framework-based sequential therapeutic strategy for the treatment of periodontitis

) and eliminate ROS inhibition of pro-inflammatory factors, such as TNF-α and IL-6. Validation in a rat periodontitis model confirmed the system's efficacy in reducing alveolar bone resorption and enhancing periodontal healing efficiency. This strategy of coordinating antibacterial and anti-inflammatory effects through the temporal regulation of drug release provides a novel therapeutic approach for bacteria-driven diseases.