Identification of the Shared Gene Signatures and Pathways Between Polycystic Ovary Syndrome and Endometrial Cancer Using Bioinformatics and Mendelian Randomization Analyses

This study, for the first time, systematically investigated the potential association between PCOS and EC through an integrative approach combining bioinformatics analysis and MR analysis. Type I interferon signaling pathway played key regulatory effect in PCOS and EC. Eight genes, such as MMP9, PECAM1 and CYBB, may be key markers linking PCOS and EC.