Stimuli-Responsive Cycloaurated ‘OFF-ON’ Switchable Anion Transporters

Anion transporters have shown potential application as anti-cancer agents that function by disrupting homeostasis and triggering cell death. In this research article we report switchable anion transport by gold complexes of anion transporters that are ‘switched on’ <i>in situ</i> in the presence of the reducing agent GSH by decomplexation of gold. GSH is found in higher concentrations in tumours than in healthy tissue and hence this approach offers a strategy to target these systems to tumours.<br>