Population pharmacokinetics of linezolid and its major metabolites PNU‐142300 and PNU‐142586 in adult patients

We developed the first population PK model in which CLcr was incorporated as a covariate in the CL of linezolid and its metabolites. Using the final model, it was possible to predict the plasma concentration, C_min , and AUC appropriately. The model was found to be a potentially useful tool for future studies on optimal dosing and toxicity analysis.