Surface Chemistry in SPR Technology

The quality of the sensor surface has a tremendous influence on the performance of the biosensor and the quality of the acquired data. This chapter invokes the treatment of the substrate, the adhesion linking layer, and the immobilization matrix, including chemistries to couple the ligands to the matrix. Furthermore, the structural features of chip surfaces for different applications are covered and an overview is provided that should be helpful in selecting the optimal surface for a given experiment.