干细胞
间充质干细胞
牙周纤维
牙周膜干细胞
干细胞移植修复关节软骨
生物
细胞生物学
成体干细胞
间充质干细胞的临床应用
组织工程
再生医学
医学
内皮干细胞
牙科
生物医学工程
体外
碱性磷酸酶
生物化学
酶
作者
Tomoaki Iwayama,Hiromi Sakashita,Masahide Takedachi,Shinya Murakami
标识
DOI:10.1016/j.jdsr.2022.04.001
摘要
Periodontal tissue stem cells, which play a crucial role in maintaining the homeostasis of periodontal tissues, are found in the periodontal ligament (PDL). These cells have long been referred to as mesenchymal stem/stromal cells (MSCs), and their clinical applications have been extensively studied. However, tissue stem cells in the PDL have not been thoroughly investigated, and they may be different from MSCs. Recent advances in stem cell biology, such as genetic lineage tracing, identification of label-retaining cells, and single-cell transcriptome analysis, have made it possible to analyze tissue stem cells in the PDL in vivo. In this review, we summarize recent findings on these stem cell populations in PDL and discuss future research directions toward developing periodontal regenerative therapy.
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