Effects of a grapeseed oil (Vitis vinifera L.) loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin: A split‐face, blinded, placebo‐controlled study

Abstract Background Worldwide, grapes ( Vitis vinifera L.; family: Vitaceae) are one of the most important fruits. Grapeseed oil is rich in bioactive constituents that could be beneficial to the health and aesthetic features of human skin. Objective This study was conducted to evaluate the effects of a novel grapeseed oil‐loaded dermocosmetic nanoemulgel on biophysical parameters of facial skin. Methods This was a split‐face, blinded, placebo‐controlled study. A novel grapeseed oil‐loaded dermocosmetic nanoemulgel was developed, and its effects on the biophysical parameters of the facial skin were evaluated and compared to those of a placebo formulation on the cheeks of 15 healthy volunteers. Melanin, erythema, sebum production, fine and large facial pores, moisture, and elasticity levels were measured using Mexameter®, Corneometer®, Sebumeter®, Cutometer®, and VisioFace®. Measurements were made on weekly basis for 12 weeks. Results Compared to the placebo, the novel grapeseed oil‐loaded dermocosmetic nanoemulgel received significantly higher sensory scores with regard to appearance, color, odor, consistency, adhesion, sensation, cohesiveness, and spreadability ( p ‐value < 0.05). Additionally, the novel nanoemulgel continuously and significantly reduced skin melanin, erythema, sebum production, and fine and large pores ( p ‐value < 0.05). On the contrary, the novel nanoemulgel continuously and significantly increased skin moisture contents and elasticity ( p ‐value < 0.05). Conclusion The novel grapeseed oil‐loaded dermocosmetic nanoemulgel had attractive cosmetic attributes that could be useful for improving imperfections of the human skin. Future studies are still needed to test and evaluate the benefits of this novel grapeseed oil‐loaded dermocosmetic nanoemulgel in disease conditions.