蛋白质组学
鉴定(生物学)
计算生物学
化学生物学
化学
质谱法
仿形(计算机编程)
纳米技术
计算机科学
生物化学
生物
色谱法
材料科学
植物
基因
操作系统
作者
Yinliang Yang,Marko Fonović,Steven H. L. Verhelst
出处
期刊:Methods in molecular biology
日期:2016-10-25
卷期号:: 185-203
被引量:17
标识
DOI:10.1007/978-1-4939-6439-0_14
摘要
The discovery of the protein targets of small molecule probes is a crucial aspect of activity-based protein profiling and chemical biology. Mass spectrometry is the primary method for target identification, and in the last decade, cleavable linkers have become a popular strategy to facilitate protein enrichment and identification. In this chapter, we provide an overview of cleavable linkers used in chemical proteomics approaches, discuss their different chemistries, and describe how they aid in protein identification.
科研通智能强力驱动
Strongly Powered by AbleSci AI