高脂血症
血脂异常
平菇
化学
食品科学
生物化学
色谱法
生物
内分泌学
糖尿病
蘑菇
作者
Yan Zhang,Zhuowei Wang,Gang Jin,Xiudong Yang,Hongli Zhou
标识
DOI:10.1016/j.ijbiomac.2017.03.084
摘要
This study was conducted to evaluate the regulating dyslipidemia effect of polysaccharides from Pleurotus ostreatus (POP) on fat-emulsion-induced hyperlipidemia rats. A plasma metabonomics method based on ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry was applied to analyze the holistic mechanism of POP in a hyperlipidemia rat model. Multivariate statistical approaches such as principal component analysis and orthogonal projection to latent structure square-discriminant analysis revealed distinctions among the control, hyperlipidemia model, and POP groups.The results demonstrated that POP had an effect on regulating dyslipidemia. The mechanism of POP on regulating dyslipidemia was partially relevant with correcting the abnormal levels of fifteen potential biomarkers towards their normal levels. These biomarkers were belong to glycerophospholipids, fatty acids, prenol lipids, sphingolipids metabolism.
科研通智能强力驱动
Strongly Powered by AbleSci AI