Primary Mucinous Carcinoma of Cowper' gland: A Case Report of a Rare Variant

Introduction : Primary carcinomas of the bulbourethral glands (Cowper’s glands) are extremely rare. Presentation of case : Herein, a 57-year-old man was presented by perineal mass for seven years. Physical examination revealed a nontender stony hard perineal mass without signs of inflammation. A urethrogram showed compression of the anterior part of the bulbous urethra. MRI of the mass revealed large perineal multilocular and marginal enhancement. The patient was managed by excision of the mass with safety margin. Histopathological examination of the mass showed remnants of malignant acini floating in pools of mucin which formed about 80% of tumor tissue Immunohistochemical analysis revealed positive reactions of the tumour cells with cytokeratin 20 but negative reactions for PSA, β-catenin and cytokeratin 7. Conclusion : We reported the first case of primary mucinous carcinoma arising in the Cowper’s glands and the 22nd in the literature of Cowper’s gland carcinoma.