突变体
多巴胺
多巴胺受体
受体
多巴胺受体D3
多巴胺受体D2
维甲酸
神经科学
化学
细胞生物学
生物
内分泌学
内科学
医学
生物化学
维甲酸
基因
作者
Wojciech Krȩz ̇el,Norbert B. Ghyselinck,Tarek A. Samad,Valérie Dupé,Philippe Kastner,Emiliana Borrelli,Pierre Chambon
出处
期刊:Science
[American Association for the Advancement of Science]
日期:1998-02-06
卷期号:279 (5352): 863-867
被引量:359
标识
DOI:10.1126/science.279.5352.863
摘要
In the adult mouse, single and compound null mutations in the genes for retinoic acid receptor β and retinoid X receptors β and γ resulted in locomotor defects related to dysfunction of the mesolimbic dopamine signaling pathway. Expression of the D1 and D2 receptors for dopamine was reduced in the ventral striatum of mutant mice, and the response of double null mutant mice to cocaine, which affects dopamine signaling in the mesolimbic system, was blunted. Thus, retinoid receptors are involved in the regulation of brain functions, and retinoic acid signaling defects may contribute to pathologies such as Parkinson's disease and schizophrenia.
科研通智能强力驱动
Strongly Powered by AbleSci AI