Production methods and properties of virus-like particles of Saccharomyces cerevisiae yeast killer strain

Based on the technology for producting virus-like particles of a killer strain of Saccharomyces cerevisiae Y-448 yeast, which includes stages of extraction, concentration, and chromatographic purification, experimental preparation samples were obtained and their properties were researched. The particle size was detected by electron microscopy. It was identified that dsRNA, which is in the composition of particles, is notable for its higher enzymatic stability as compared to loose dsRNA. It was shown in in vivo experiments that the obtained VLP preparations increase the phagocytic activity of macrophages and the interferon level in mouse blood serum to a greater extent than the drug of comparison, Rhidostin.