Reactions of Ketorolac and Its Isopropyl Ester in 35% Isopropyl Alcohol

The pH-rate profiles for the etherification and hydrolysis of ketorolac and the isopropyl ester of ketorolac have been measured in 35% isopropyl alcohol at 22, 60, and 80°C. The data showed that pH has a large effect on the rate of esterification in the pH region below pH 5. Additional studies on the hydrolysis of the isopropyl ester of ketorolac showed that acetate buffer catalyzes the hydrolysis reaction.