器官发生
基质
生物
内胚层
细胞生物学
主要组织相容性复合体
祖细胞
祖细胞
免疫学
细胞分化
干细胞
遗传学
基因
抗原
免疫组织化学
作者
Craig S. Nowell,Alison Farley,C. Clare Blackburn
出处
期刊:Methods in molecular biology
日期:2007-01-01
卷期号:: 125-162
被引量:27
标识
DOI:10.1007/978-1-59745-395-0_8
摘要
T-cell development occurs principally in the thymus. Here, immature progenitor cells are guided through the differentiation and selection steps required to generate a complex T-cell repertoire that is both self-tolerant and has propensity to bind self major histocompatibility complex. These processes depend on an array of functionally distinct epithelial cell types within the thymic stroma, which have a common developmental origin in the pharyngeal endoderm. Here, we describe the structural and phenotypic attributes of the thymic stroma, and review current cellular and molecular understanding of thymus organogenesis.
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