Mild and Reversible Friedel-Crafts Acylation: Synthesis of 6-Acyl-2-methoxynaphthalenes

Abstract A new practical method for large scale preparation of 2-acyl-6-methoxynaphthalenes 3 is reported. The selectivity toward 3 is due to reversibility of the Friedel-Crafts acylation and to the thermodynamic stability of 3.