Prenatal cfDNA Sequencing and Incidental Detection of Maternal Cancer

To the Editor: In their article on the Incidental Detection of Maternal Neoplasia through Noninvasive Cell-free DNA Analysis (IDENTIFY) study, Turriff et al. (Dec. 5 issue) 1 discuss nonreportable results of cell-free DNA (cfDNA) tests during pregnancy and their association with the risk of occult maternal cancer. They report that they “detected cancer in 48.6% of participants who initially received nonreportable or unusual cfDNA-sequencing results.” This statement could benefit from being contextualized, given three factors: the study population is highly selective in that it excludes patients with nonreportable results caused by insufficient fetal fraction or other technical issues; the incidence of . . .