溃疡性结肠炎
植物乳杆菌
结肠炎
炎症
短链脂肪酸
肠道菌群
乳酸菌
微生物学
化学
细菌
免疫学
生物
生物化学
乳酸
医学
疾病
发酵
内科学
丁酸盐
遗传学
作者
Qing Gu,Chenlan Xia,Nana Liu,Ziqi Chen,Qingqing Zhou,Ping Li
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2023-01-01
卷期号:14 (9): 3982-3993
被引量:6
摘要
Ulcerative colitis is an inflammatory bowel disease that is mainly related to gut microbiota dysbiosis. Lactobacillus plantarum ZJ316 (ZJ316) has been proved to regulate the gut microbiota in vitro. However, more evidence is needed for the intestinal effects of ZJ316 in vivo. Colitis was induced via dissolved 2.5% DSS in drinking water for 7 days in 8-week-old BALB/c mice, which were then fed with ZJ316 (1 × 108 CFU mL-1) for 35 days. After ZJ316 intervention, the dextran sulfate sodium salt (DSS)-induced colitis symptoms were remarkably alleviated, including recovery of body weight and colon weight and effective inhibition of the expression of pro-inflammatory cytokines. Results based on 16S rRNA gene sequencing indicated that the structure of the gut microbiota in ZJ316 supplementation was markedly altered by upregulating the percentage of Firmicutes while reducing the percentage of Bacteroidetes. Furthermore, the colon contained more short-chain fatty acids (SCFAs) and butyrate-producing genera, such as Faecalibacterium, Agathobacter, and Roseburia. Spearman correlation analysis indicated that SCFAs, especially butyric acid, were positively associated with Faecalibacterium and Agathobacter. Our study suggested that ZJ316 could be used to relieve ulcerative colitis (UC) as dietary therapeutics.
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