Insights into psychosis risk: Unveiling impaired reinforcement learning through a behavioral and functional near-infrared spectroscopy-based optical neuroimaging study

Our findings indicate impaired reward feedback processing in CHR-P subjects, suggesting reduced sensitivity to reward. This is reflected in decreased task-induced response in cerebrovascular [tHb], indicating lower task-relevant prefrontal activities compared to HC subjects. These findings suggest that impaired processing of reward feedback may contribute to reward learning deficits and inflexible cognition in CHR-P subjects.