Synthesis of Novel Substituted Bis(benzimidazole)amine, N-Benzimidazole (benzothiazole)amine, and N-Benzimidazole(benzoxazole)amine Under Ultrasound Irradiation via Copper-Catalyzed Reaction

In this work, novel bis(benzimidazole)amine, N-benzimidazole(benzothiazole)amine, and N-benzimidazole(benzoxazole)amine have been synthesized via a one-pot, intramolecular cyclization of 2-iodoaniline and 2-aminobenzimidazoles (thiazoles and oxazoles)-trichloroacetonitrile adduct using copper(I) iodide and DMF under ultrasound-assisted reaction with moderate to good yields. Using basic materials and simple and available reagents, gentle copper-catalyzed reaction conditions, easy purification with the help of solvent, good yields, non-addition of ligands, application of a simple and efficient sonochemical method, short reaction times, and the synthesis of 15 new heterocycle compounds have been appreciable features of this protocol.