Osteoporosis Caused by Monoallelic Variant of WNT1 Gene in Four Pediatric Patients

. Our data showed that the age of onset of osteoporosis by monoallelic variants in WNT1 is significantly earlier than the age of onset in the general population. Severe osteoporosis is also exhibited in pediatric patients, not just in aging patients with WNT1 variant. Zoledronic acid treatment is effective in short-term observation for pediatric patients with improvement of bone pain and BMD, and no more facture during treatment.