Synthesis of allenones via nickel-catalyzed reductive coupling of propargyl esters with acyl chlorides

Abstract

Transition metal-catalyzed reductive coupling of two electrophilic components has proved to be a powerful and step-economic tool for forging diverse organic molecules. However, the application of such strategy for the synthesis of allenones that are very important in pharmaceutical chemistry and synthetic chemistry remains very limited and challenging. Herein, we have developed a nickel-catalyzed reductive cross-coupling of propargyl esters with acyl chlorides, which affords an alternative route for the synthesis of allenones. The current catalytic protocol features readily available starting materials, wide substrate scope, mild conditions and good regioselectivity.