A systematic review on electrochemical sensors for the detection of acetaminophen

Considerable progress has been made in the electrochemical determination of acetaminophen (AP) over the past few decades. Nanomaterials or enzymes as electrode modifiers greatly improve the performance of AP electrochemical sensors. This review focuses on the development potential, detection principles and techniques for the electrochemical analysis of AP. In particular, the design and construction of AP electrochemical sensors are discussed from the perspective of non-enzyme materials (such as nanomaterials, including precious metals, transition metals and non-metals) and enzyme substances (such as aryl acylamidase, polyphenol oxidase and horseradish peroxidase). Moreover, the influencing factors for AP electrochemical sensors and the simultaneous detection of AP and other targets are summarized, and the future prospective of AP electrochemical sensors is outlined. This review provides a reference and guidance for the development and application of electrochemical sensors for AP detection.