Engineering the endometrium

Endometrial tissue is a dynamic environment that regenerates alongside the menstrual cycle and in response to sex hormones. This month in Med, Gnecco and colleagues 1 Gnecco J.S. Brown A. Buttrey K. Ives C. Goods B.A. Baugh L. Hernandez-Gordillo V. Loring M. Isaacson K. Griffith L.G. Organoid co-culture model of the cycling human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk. Med. 2023; 4: 554-579 Abstract Full Text Full Text PDF Scopus (1) Google Scholar present an innovative, synthetic model of endometrial environment that supports long-term cultures, simulates a 28-day menstrual cycle, and could be employed to investigate reproductive pathophysiology. Endometrial tissue is a dynamic environment that regenerates alongside the menstrual cycle and in response to sex hormones. This month in Med, Gnecco and colleagues 1 Gnecco J.S. Brown A. Buttrey K. Ives C. Goods B.A. Baugh L. Hernandez-Gordillo V. Loring M. Isaacson K. Griffith L.G. Organoid co-culture model of the cycling human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk. Med. 2023; 4: 554-579 Abstract Full Text Full Text PDF Scopus (1) Google Scholar present an innovative, synthetic model of endometrial environment that supports long-term cultures, simulates a 28-day menstrual cycle, and could be employed to investigate reproductive pathophysiology. Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalkGnecco et al.MedAugust 11, 2023In BriefGnecco and Brown et al. develop a synthetic extracellular matrix that establishes a novel co-culture model of endometrial stromal and epithelial organoids in a controlled and tunable biomaterial. This allows the study of hormone-mediated processes of the human menstrual cycle in vitro and analysis of cell-cell and cell-extracellular matrix interactions. Full-Text PDF