Disturbed Sleep Supports Neutrophil Activation and Promotes Atherosclerosis and Plaque Necrosis

HomeCirculation ResearchVol. 133, No. 12Disturbed Sleep Supports Neutrophil Activation and Promotes Atherosclerosis and Plaque Necrosis No AccessResearch ArticleRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessResearch ArticleRequest AccessFull TextDisturbed Sleep Supports Neutrophil Activation and Promotes Atherosclerosis and Plaque Necrosis Alina K. Moriarty, Tayab C. Waseem, W. Coles Keeter, Shelby D. Ma, Robin Bai, Aleksandr V. Ivanov, Cassandra L. Kirk, Marion Mussbacher, Larry D. Sanford and Elena V. Galkina Alina K. MoriartyAlina K. Moriarty https://orcid.org/0009-0002-6402-4661 Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Center for Integrative Neuroscience and Inflammatory Diseases (A.K.M., L.D.S., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , Tayab C. WaseemTayab C. Waseem Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , W. Coles KeeterW. Coles Keeter Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , Shelby D. MaShelby D. Ma Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , Robin BaiRobin Bai Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , Aleksandr V. IvanovAleksandr V. Ivanov Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , Cassandra L. KirkCassandra L. Kirk Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author , Marion MussbacherMarion Mussbacher https://orcid.org/0000-0001-5346-6785 Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Now with Department of Pharmacology and Toxicology, University of Graz, Austria (M.M.). Search for more papers by this author , Larry D. SanfordLarry D. Sanford Department of Anatomy and Pathology (L.D.S.), Eastern Virginia Medical School. Center for Integrative Neuroscience and Inflammatory Diseases (A.K.M., L.D.S., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author and Elena V. GalkinaElena V. Galkina Correspondence to: Elena V. Galkina, PhD, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W. Olney Rd, LH3180, Norfolk, VA 23507. Email E-mail Address: [email protected] Department of Microbiology and Molecular Cell Biology (A.K.M., T.C.W., W.C.K., S.D.M., R.B., A.V.I., C.L.K., M.M., E.V.G.), Eastern Virginia Medical School. Center for Integrative Neuroscience and Inflammatory Diseases (A.K.M., L.D.S., E.V.G.), Eastern Virginia Medical School. Search for more papers by this author Originally published10 Nov 2023https://doi.org/10.1161/CIRCRESAHA.123.322858Circulation Research. 2023;133:1056–1059is related toMeet the First AuthorsFootnotesFor Sources of Funding and Disclosures, see page 1059.Correspondence to: Elena V. Galkina, PhD, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, 700 W. Olney Rd, LH3180, Norfolk, VA 23507. Email galkinev@evms.eduREFERENCES1. McAlpine CS, Kiss MG, Rattik S, He S, Vassalli A, Valet C, Anzai A, Chan CT, Mindur JE, et al. Sleep modulates haematopoiesis and protects against atherosclerosis.Nature. 2019; 566:383–387. doi: 10.1038/s41586-019-0948-2CrossrefMedlineGoogle Scholar2. Ramesh V, Nair D, Zhang SX, Hakim F, Kaushal N, Kayali F, Wang Y, Li RC, Carreras A, Gozal D. Disrupted sleep without sleep curtailment induces sleepiness and cognitive dysfunction via the tumor necrosis factor-α pathway.J Neuroinflammation. 2012; 9:91. doi: 10.1186/1742-2094-9-91CrossrefMedlineGoogle Scholar3. Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, et al. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.Nature. 2019; 569:236–240. doi: 10.1038/s41586-019-1167-6CrossrefMedlineGoogle Scholar4. Mehrpouya-Bahrami P, Moriarty AK, De Melo P, Keeter WC, Alakhras NS, Nelson AS, Hoover M, Barrios MS, Nadler JL, Serezani CH., et al. STAT4 is expressed in neutrophils and promotes antimicrobial immunity.JCI insight. 2021; 22:e141326. doi: 10.1172/jci.insight.141326CrossrefGoogle Scholar5. Boivin G, Faget J, Ancey PB, Gkasti A, Mussard J, Engblom C, Pfirschke C, Contat C, Pascual J, Vazquez J, et al. Durable and controlled depletion of neutrophils in mice.Nat Commun. 2020; 11:2762. doi: 10.1038/s41467-020-16596-9CrossrefMedlineGoogle Scholar eLetters(0) eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. Authors of the article cited in the comment will be invited to reply, as appropriate. Comments and feedback on AHA/ASA Scientific Statements and Guidelines should be directed to the AHA/ASA Manuscript Oversight Committee via its Correspondence page. Sign In to Submit a Response to This Article Previous Back to top Next FiguresReferencesRelatedDetailsRelated articlesMeet the First AuthorsCirculation Research. 2023;133:964-965 December 8, 2023Vol 133, Issue 12 Advertisement Article Information Metrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.322858PMID: 37947098 Originally publishedNovember 10, 2023 Keywordsatherosclerosisneutrophilsplaque necrosissleep fragmentationPDF download Advertisement Subjects Animal Models of Human Disease Inflammation