程序性细胞死亡
上睑下垂
细胞凋亡
癌细胞
自噬
治疗方式
癌症研究
线粒体
坏死性下垂
癌症
坏死
生物
细胞生物学
医学
生物化学
遗传学
内科学
作者
Xiaodan Zhang,Tao Tao,Yue Qiu,Xiaojun Guo,Xiao Zhu,Xiaorong Zhou
标识
DOI:10.1016/j.biopha.2023.115730
摘要
Previous investigations have unraveled an array of cellular demise modalities, encompassing apoptosis, necrosis, pyroptosis, iron death, and several others. These diverse pathways of cell death have been harnessed as therapeutic strategies for eradicating tumor cells. Recent scientific inquiries have unveiled a novel mode of cell death, namely copper death, which is contingent upon intracellular copper levels. Diverging from conventional cell death mechanisms, copper death exhibits a heightened reliance on mitochondrial respiration, specifically the tricarboxylic acid (TCA) cycle. Tumor cells exhibit distinctive metabolic profiles and an elevated copper content compared to their normal counterparts. The emergence of copper death presents a tantalizing prospect for targeted therapies in the realm of cancer treatment. Thus, the primary objective of this review is to introduce the proteins and intricate mechanisms underlying copper death, while comprehensively summarizing the extensive body of knowledge concerning its ramifications across diverse tumor types. The insights garnered from this comprehensive synthesis will serve as an invaluable reference for driving the development of tailor-made therapeutic interventions for tumors.
科研通智能强力驱动
Strongly Powered by AbleSci AI